A new study published in the Molecular Psychiatry journal reports that researchers have found a mutation in a gene that causes bipolar disorder in as many as ten percent of cases. This is fantastic news! Finally, the causes of bipolar disorder are starting to be pinpointed.
The gene, G protein receptorkinase 3 (GRK3), regulates neurotransmitters such as dopamine. The mutation happens in a section of the gene called the promoter, which turns GRK3 on and off. Scientists at the University of California, San Diego (UCSD) School of Medicine hypothesize that what causes bipolar disorder is that the mutation makes the gene hypersensitive to dopamine.
The study took place over a year, and screened DNA samples from more than 400 families with bipolar disorder. The researchers found six mutations in the promoter region of GRK3. Most notable was that the P-5 mutation happened three times more frequently in people who suffer from bipolar disorder than those who don’t.
Research has long pointed to several genes being the causes of bipolar disorder. But this is the first time a single gene has been determined as a cause. Bipolar disorder is characterized by extreme highs and lows. Few therapies work to treat the mental illness, and those that do work aren’t effective for all people who suffer from it. The scientists involved in this study hope that specific therapies that target genes on a molecular level will be developed.